Version 5.4
Homo sapiens Protein: HYAL3
Summary
InnateDB Protein IDBP-36312.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HYAL3
Protein Name hyaluronoglucosaminidase 3
Synonyms HYAL-3; LUCA-3; LUCA3;
Species Homo sapiens
Ensembl Protein ENSP00000351946
InnateDB Gene IDBG-36306 (HYAL3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Secreted {ECO:0000250}. Lysosome {ECO:0000250}.
Disease Associations
Tissue Specificity Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells. {ECO:0000269PubMed:10493834, ECO:0000269PubMed:12084718}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004415 hyalurononglucosaminidase activity
GO:0033906 hyaluronoglucuronidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006954 inflammatory response
GO:0009615 response to virus
GO:0030214 hyaluronan catabolic process
GO:0046677 response to antibiotic
GO:0051216 cartilage development
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071493 cellular response to UV-B
Cellular Component
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR017853 Glycoside hydrolase, superfamily
IPR018155 Hyaluronidase
PFAM PF01630
PRINTS PR00846
PIRSF PIRSF038193
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43820
PhosphoSite PhosphoSite-
TrEMBL C9JB51
UniProt Splice Variant
Entrez Gene 8372
UniGene Hs.732895
RefSeq
HUGO HGNC:5322
OMIM 604038
CCDS CCDS56257
HPRD
IMGT
EMBL AF036035 AF040710 AF502909 AF502910 AF502911 AF502912 BC005896 BC012892 U73167
GenPept AAC02729 AAC70915 AAD04257 AAH05896 AAH12892 AAM60775 AAM60776 AAM60777 AAM60778

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca