InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HRH1

Summary

InnateDB Protein

IDBP-363289.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HRH1

Protein Name

histamine receptor H1

Synonyms

H1-R; hisH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000397028

InnateDB Gene

IDBG-18663 (HRH1)

Protein Structure

UniProt Annotation

Function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:21697825}; Multi-pass membrane protein {ECO:0000269PubMed:21697825}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0043114	regulation of vascular permeability
GO:0045907	positive regulation of vasoconstriction
GO:0048016	inositol phosphate-mediated signaling
GO:0048245	eosinophil chemotaxis
GO:0071420	cellular response to histamine

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000921 Histamine H1 receptor
IPR000995 Muscarinic acetylcholine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00530
PR00243

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35367