Version 5.4
Homo sapiens Protein: TMEM214
Summary
InnateDB Protein IDBP-36467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM214
Protein Name transmembrane protein 214
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000319469
InnateDB Gene IDBG-36463 (TMEM214)
Protein Structure
UniProt Annotation
Function Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress. {ECO:0000269PubMed:23661706}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:23661706}; Multi-pass membrane protein {ECO:0000269PubMed:23661706}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005881 cytoplasmic microtubule
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR019308 Protein of unknown function DUF2359, TMEM214
PFAM PF10151
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NUQ4
PhosphoSite PhosphoSite-Q6NUQ4
TrEMBL B2RD07
UniProt Splice Variant
Entrez Gene 54867
UniGene Hs.533934
RefSeq
HUGO HGNC:25983
OMIM 615301
CCDS CCDS42664
HPRD 07887
IMGT
EMBL AC013472 AF289555 AK000261 AK074981 AK097308 AK315359 AL833725 BC068479 CH471053
GenPept AAH68479 AAL55739 AAY14654 BAA91038 BAC11331 BAG37754 BAG53451 CAH10591 EAX00655 EAX00657 EAX00659

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca