InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HYAL2

Summary

InnateDB Protein

IDBP-36559.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HYAL2

Protein Name

hyaluronoglucosaminidase 2

Synonyms

LUCA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000350387

InnateDB Gene

IDBG-36557 (HYAL2)

Protein Structure

UniProt Annotation

Function

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. {ECO:0000269PubMed:11296287, ECO:0000269PubMed:12676986, ECO:0000269PubMed:9712871}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11296287}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:11296287}.

Disease Associations

Tissue Specificity

Widely expressed. No expression detected in adult brain. {ECO:0000269PubMed:9712871}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004415	hyalurononglucosaminidase activity
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0019899	enzyme binding
GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity
GO:0030971	receptor tyrosine kinase binding
GO:0033906	hyaluronoglucuronidase activity
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001822	kidney development
GO:0005975	carbohydrate metabolic process
GO:0006027	glycosaminoglycan catabolic process
GO:0009615	response to virus
GO:0010764	negative regulation of fibroblast migration
GO:0019064	fusion of virus membrane with host plasma membrane
GO:0019087	transformation of host cell by virus
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0030308	negative regulation of cell growth
GO:0035810	positive regulation of urine volume
GO:0042117	monocyte activation
GO:0042307	positive regulation of protein import into nucleus
GO:0043407	negative regulation of MAP kinase activity
GO:0044281	small molecule metabolic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046677	response to antibiotic
GO:0046718	viral entry into host cell
GO:0050729	positive regulation of inflammatory response
GO:0051216	cartilage development
GO:0051898	negative regulation of protein kinase B signaling
GO:0061099	negative regulation of protein tyrosine kinase activity
GO:0070295	renal water absorption
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071493	cellular response to UV-B
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2000484	positive regulation of interleukin-8 secretion
GO:2000778	positive regulation of interleukin-6 secretion
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0009986	cell surface
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016324	apical plasma membrane
GO:0030139	endocytic vesicle
GO:0031362	anchored component of external side of plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0045121	membrane raft
GO:0046658	anchored component of plasma membrane
GO:0048471	perinuclear region of cytoplasm