Version 5.4
Homo sapiens Protein: AGR2
Summary
InnateDB Protein IDBP-366248.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGR2
Protein Name anterior gradient homolog 2 (Xenopus laevis)
Synonyms AG2; GOB-4; HAG-2; HEL-S-116; PDIA17; XAG-2;
Species Homo sapiens
Ensembl Protein ENSP00000391490
InnateDB Gene IDBG-8965 (AGR2)
Protein Structure
UniProt Annotation
Function Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. {ECO:0000250, ECO:0000269PubMed:18199544}.
Subcellular Localization Secreted {ECO:0000269PubMed:15834940}. Endoplasmic reticulum {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. {ECO:0000269PubMed:9790916}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002162 dystroglycan binding
GO:0005515 protein binding
Biological Process
GO:0060480 lung goblet cell differentiation
GO:0070254 mucus secretion
Cellular Component
GO:0005576 extracellular region
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro IPR012336 Thioredoxin-like fold
PFAM PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95994
PhosphoSite PhosphoSite-O95994
TrEMBL Q4JM47
UniProt Splice Variant
Entrez Gene 10551
UniGene
RefSeq NP_006399
HUGO HGNC:328
OMIM 606358
CCDS CCDS5364
HPRD 05896
IMGT
EMBL AC073333 AF007791 AF038451 AF087879 AF088867 AF115926 AY359009 BC015503 BT007048 CH236948 CH471073 DQ070893 FJ224307
GenPept AAC77358 AAC82614 AAF22484 AAH15503 AAL54870 AAP22354 AAP35697 AAP97179 AAQ89368 AAY84773 AAY84774 ACI45999 EAL24283 EAW93682 EAW93683

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca