InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMPRSS3

Summary

InnateDB Protein

IDBP-368171.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMPRSS3

Protein Name

transmembrane protease, serine 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000411013

InnateDB Gene

IDBG-4346 (TMPRSS3)

Protein Structure

UniProt Annotation

Function

Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). {ECO:0000250, ECO:0000269PubMed:12393794}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12393794}; Single-pass type II membrane protein {ECO:0000269PubMed:12393794}.

Disease Associations

Deafness, autosomal recessive, 8 (DFNB8) [MIM:601072]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity

Biological Process

GO:0006508	proteolysis
GO:0006883	cellular sodium ion homeostasis
GO:0006898	receptor-mediated endocytosis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017448 SRCR-like domain

PFAM

PF00530
PF00089
PF00057
PF09342

PRINTS

PR00258
PR00722
PR00261

PIRSF

SMART

SM00020
SM00192
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt