Homo sapiens Protein: TMX1
Summary
InnateDB Protein IDBP-368643.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMX1
Protein Name thioredoxin-related transmembrane protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000393316
InnateDB Gene IDBG-6529 (TMX1)
Protein Structure
UniProt Annotation
Function May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly found in the endoplasmic reticulum. {ECO:0000269PubMed:11152479}.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in kidney, liver, placenta and lung.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0015036 disulfide oxidoreductase activity
Biological Process
GO:0006457 protein folding
GO:0034976 response to endoplasmic reticulum stress
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H3N1
PhosphoSite PhosphoSite-Q9H3N1
TrEMBL
UniProt Splice Variant
Entrez Gene 81542
UniGene Hs.607313
RefSeq NP_110382
HUGO HGNC:15487
OMIM 610527
CCDS CCDS41953
HPRD 15590
IMGT
EMBL AB048246 AK075395 AK312905 AL080080 AL591807 AY358640 BC036460 BC056874 CH471078
GenPept AAH36460 AAH56874 AAQ89003 BAB20629 BAC11593 BAG35751 CAB45700 EAW65678