Version 5.4
Homo sapiens Protein: TMEM8B
Summary
InnateDB Protein IDBP-368952.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM8B
Protein Name transmembrane protein 8B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000395810
InnateDB Gene IDBG-64450 (TMEM8B)
Protein Structure
UniProt Annotation
Function May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. {ECO:0000269PubMed:15498789, ECO:0000269PubMed:15723283, ECO:0000269PubMed:17270023, ECO:0000269PubMed:17641538}.
Subcellular Localization Isoform 2: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic reticulum.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0007160 cell-matrix adhesion
GO:0007346 regulation of mitotic cell cycle
GO:0040008 regulation of growth
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003614 Knottin, scorpion toxin-like
IPR021910 Protein of unknown function DUF3522
PFAM PF12036
PRINTS
PIRSF
SMART SM00505
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6NDV4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 51754
UniGene Hs.493808
RefSeq NP_057530
HUGO HGNC:21427
OMIM
CCDS CCDS6595
HPRD 16674
IMGT
EMBL AF070572 AF149297 AF188239 AK074844 AL133410 BC041377 BC098265 BC098296 BC099733 CH471071
GenPept AAC28644 AAF34820 AAG29055 AAH98265 AAH98296 AAH99733 BAG52015 CAI10995 CAI10996 EAW58325

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca