InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G10

Summary

InnateDB Protein

IDBP-369121.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G10

Protein Name

phospholipase A2, group X

Synonyms

GXPLA2; GXSPLA2; SPLA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000393847

InnateDB Gene

IDBG-15446 (PLA2G10)

Protein Structure

UniProt Annotation

Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0004623	phospholipase A2 activity
GO:0005509	calcium ion binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0007411	axon guidance
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010884	positive regulation of lipid storage
GO:0016042	lipid catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032308	positive regulation of prostaglandin secretion
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0042632	cholesterol homeostasis
GO:0043030	regulation of macrophage activation
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0051977	lysophospholipid transport
GO:0090238	positive regulation of arachidonic acid secretion
GO:0090370	negative regulation of cholesterol efflux