InnateDB Protein
|
IDBP-36929.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PPP1R3A
|
Protein Name
|
protein phosphatase 1, regulatory subunit 3A
|
Synonyms
|
GM; PP1G; PPP1R3;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000284601
|
InnateDB Gene
|
IDBG-36927 (PPP1R3A)
|
Protein Structure
|
|
Function |
Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
|
Disease Associations |
Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:7926294}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
|
Tissue Specificity |
Skeletal muscle and heart. {ECO:0000269PubMed:9726244}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR005036
Putative phosphatase regulatory subunit
|
PFAM |
PF03370
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q16821
|
PhosphoSite |
PhosphoSite-Q16821
|
TrEMBL |
C9JZB3
|
UniProt Splice Variant |
|
Entrez Gene |
5506
|
UniGene |
Hs.458309
|
RefSeq |
NP_002702
|
HUGO |
HGNC:9291
|
OMIM |
600917
|
CCDS |
CCDS5759
|
HPRD |
02950
|
IMGT |
|
EMBL |
AC092465
AC092606
AC093598
AF024576
AF024577
AF024578
AF024579
BC126451
BC126453
CH236947
X78578
|
GenPept |
AAB94596
AAB94597
AAI26452
AAI26454
AAP22361
AAS07492
CAA55316
EAL24370
|
|
|