InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1R3A

Summary

InnateDB Protein

IDBP-36931.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R3A

Protein Name

protein phosphatase 1, regulatory subunit 3A

Synonyms

GM; PP1G; PPP1R3;

Species

Homo sapiens

Ensembl Protein

ENSP00000284602

InnateDB Gene

IDBG-36927 (PPP1R3A)

Protein Structure

UniProt Annotation

Function

Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:7926294}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Skeletal muscle and heart. {ECO:0000269PubMed:9726244}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.