InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTATIP2

Summary

InnateDB Protein

IDBP-369357.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTATIP2

Protein Name

HIV-1 Tat interactive protein 2, 30kDa

Synonyms

CC3; SDR44U1; TIP30;

Species

Homo sapiens

Ensembl Protein

ENSP00000387876

InnateDB Gene

IDBG-35847 (HTATIP2)

Protein Structure

UniProt Annotation

Function

Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. {ECO:0000269PubMed:10611237, ECO:0000269PubMed:11313954, ECO:0000269PubMed:15282309, ECO:0000269PubMed:9174052}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15282309}. Nucleus envelope {ECO:0000269PubMed:15282309}.

Disease Associations

Tissue Specificity

Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas. {ECO:0000269PubMed:14695192, ECO:0000269PubMed:9174052}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0001525	angiogenesis
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0016032	viral process
GO:0030154	cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0045765	regulation of angiogenesis
GO:0051170	nuclear import
GO:0055114	oxidation-reduction process