InnateDB Protein
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IDBP-369360.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HTATIP2
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Protein Name
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HIV-1 Tat interactive protein 2, 30kDa
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Synonyms
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CC3; SDR44U1; TIP30;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000392985
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InnateDB Gene
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IDBG-35847 (HTATIP2)
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Protein Structure
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Function |
Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. {ECO:0000269PubMed:10611237, ECO:0000269PubMed:11313954, ECO:0000269PubMed:15282309, ECO:0000269PubMed:9174052}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15282309}. Nucleus envelope {ECO:0000269PubMed:15282309}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas. {ECO:0000269PubMed:14695192, ECO:0000269PubMed:9174052}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003713
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transcription coactivator activity
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GO:0005515
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protein binding
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GO:0016491
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oxidoreductase activity
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GO:0016620
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oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
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GO:0051287
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NAD binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000534
Semialdehyde dehydrogenase, NAD-binding
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PFAM |
PF01118
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PRINTS |
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PIRSF |
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SMART |
SM00859
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BUP3
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PhosphoSite |
PhosphoSite-Q9BUP3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10553
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UniGene |
Hs.90753
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RefSeq |
NP_001091990
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HUGO |
HGNC:16637
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OMIM |
605628
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CCDS |
CCDS44553
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HPRD |
09288
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IMGT |
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EMBL |
AC025972
AF039103
AF092095
AK222969
AK223010
AK292092
BC002439
BC015358
CH471064
CR456821
U69161
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GenPept |
AAB84360
AAC39694
AAC78331
AAH02439
AAH15358
BAD96689
BAD96730
BAF84781
CAG33102
EAW68338
EAW68339
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