Version 5.4
Homo sapiens Protein: TRAPPC9
Summary
InnateDB Protein IDBP-36974.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAPPC9
Protein Name trafficking protein particle complex 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000373979
InnateDB Gene IDBG-36970 (TRAPPC9)
Protein Structure
UniProt Annotation
Function Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000269PubMed:15951441}.
Subcellular Localization Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Processes and cell bodies of neurons. {ECO:0000250}.
Disease Associations Mental retardation, autosomal recessive 13 (MRT13) [MIM:613192]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Brain magnetic resonance imaging of MRT13 patients indicates the presence of mild cerebral white matter hypoplasia. Microcephaly is present in some but not all affected individuals. {ECO:0000269PubMed:20004763, ECO:0000269PubMed:20004765}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta. {ECO:0000269PubMed:15951441}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0030154 cell differentiation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID
InterPro IPR013935 TRAPP II complex, Trs120
PFAM PF08626
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96Q05
PhosphoSite PhosphoSite-Q96Q05
TrEMBL
UniProt Splice Variant
Entrez Gene 83696
UniGene Hs.690965
RefSeq NP_113654
HUGO HGNC:30832
OMIM 611966
CCDS CCDS34946
HPRD 18136
IMGT
EMBL AB067469 AK027689 AK128755 AL833973 AY190606 AY630619 BC003650 BC006206 BC065288
GenPept AAH03650 AAH06206 AAH65288 AAO38740 AAV31908 BAB55299 BAB67775 BAC87600 CAH56384

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca