Version 5.4
Homo sapiens Protein: TMEM115
Summary
InnateDB Protein IDBP-36987.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM115
Protein Name transmembrane protein 115
Synonyms PL6;
Species Homo sapiens
Ensembl Protein ENSP00000266025
InnateDB Gene IDBG-36985 (TMEM115)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013861 Protein of unknown function DUF1751, integral membrane, eukaryotic
PFAM PF08551
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q12893
PhosphoSite PhosphoSite-Q12893
TrEMBL A0A024R2Y2
UniProt Splice Variant
Entrez Gene 11070
UniGene Hs.91566
RefSeq NP_008955
HUGO HGNC:30055
OMIM 607069
CCDS CCDS2828
HPRD 06144
IMGT
EMBL AC002481 BC011948 BC017367 CH471055 CR457020 U09584 Z84492
GenPept AAA92281 AAB67308 AAH11948 AAH17367 CAG33301 CAM28372 EAW65115 EAW65116

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca