InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BDNF

Summary

InnateDB Protein

IDBP-369990.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BDNF

Protein Name

brain-derived neurotrophic factor

Synonyms

ANON2; BULN2;

Species

Homo sapiens

Ensembl Protein

ENSP00000414303

InnateDB Gene

IDBG-36817 (BDNF)

Protein Structure

UniProt Annotation

Function

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {ECO:0000269PubMed:12553913}.

Subcellular Localization

Secreted.

Disease Associations

Congenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. {ECO:0000269PubMed:11840487}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta. {ECO:0000269PubMed:17629449}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005169	neurotrophin TRKB receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001657	ureteric bud development
GO:0001662	behavioral fear response
GO:0001666	response to hypoxia
GO:0002544	chronic inflammatory response
GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007399	nervous system development
GO:0007406	negative regulation of neuroblast proliferation
GO:0007411	axon guidance
GO:0007412	axon target recognition
GO:0007611	learning or memory
GO:0007612	learning
GO:0007623	circadian rhythm
GO:0007631	feeding behavior
GO:0008038	neuron recognition
GO:0009416	response to light stimulus
GO:0009642	response to light intensity
GO:0009725	response to hormone
GO:0010996	response to auditory stimulus
GO:0014047	glutamate secretion
GO:0014076	response to fluoxetine
GO:0014823	response to activity
GO:0016358	dendrite development
GO:0019222	regulation of metabolic process
GO:0021675	nerve development
GO:0030516	regulation of axon extension
GO:0031667	response to nutrient levels
GO:0032094	response to food
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033189	response to vitamin A
GO:0034612	response to tumor necrosis factor
GO:0035864	response to potassium ion
GO:0042490	mechanoreceptor differentiation
GO:0042493	response to drug
GO:0042596	fear response
GO:0043066	negative regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045666	positive regulation of neuron differentiation
GO:0045843	negative regulation of striated muscle tissue development
GO:0046668	regulation of retinal cell programmed cell death
GO:0048167	regulation of synaptic plasticity
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048170	positive regulation of long-term neuronal synaptic plasticity
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0048675	axon extension
GO:0048839	inner ear development
GO:0050890	cognition
GO:0051602	response to electrical stimulus
GO:0051965	positive regulation of synapse assembly
GO:0055093	response to hyperoxia
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060548	negative regulation of cell death
GO:0061193	taste bud development
GO:0071356	cellular response to tumor necrosis factor
GO:0071874	cellular response to norepinephrine stimulus
GO:0072347	response to anesthetic
GO:0097484	dendrite extension
GO:1901215	negative regulation of neuron death
GO:1902065	response to L-glutamate
GO:1990089	response to nerve growth factor
GO:1990090	cellular response to nerve growth factor stimulus
GO:1990138	neuron projection extension

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0008021	synaptic vesicle
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030061	mitochondrial crista
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm