Version 5.4
Homo sapiens Protein: PLEKHA8
Summary
InnateDB Protein IDBP-370445.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHA8
Protein Name pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000397947
InnateDB Gene IDBG-10971 (PLEKHA8)
Protein Structure
UniProt Annotation
Function Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. {ECO:0000269PubMed:15107860, ECO:0000269PubMed:16103222, ECO:0000269PubMed:17687330}.
Subcellular Localization Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein. Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes.
Disease Associations
Tissue Specificity Expressed in kidney cell lines. {ECO:0000269PubMed:15107860}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017089 glycolipid transporter activity
GO:0051861 glycolipid binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0097001 ceramide binding
Biological Process
GO:0006869 lipid transport
GO:0015031 protein transport
GO:0035621 ER to Golgi ceramide transport
GO:0046836 glycolipid transport
Cellular Component
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
IPR014830 Glycolipid transfer protein domain
PFAM PF00169
PF08718
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JA3
PhosphoSite PhosphoSite-Q96JA3
TrEMBL
UniProt Splice Variant
Entrez Gene 84725
UniGene Hs.734170
RefSeq NP_001183955
HUGO HGNC:30037
OMIM 608639
CCDS CCDS56473
HPRD 10555
IMGT
EMBL AF308300 AF380162 AK023180 AK294857 BC002838 BC053990 CH471073
GenPept AAG48267 AAH02838 AAH53990 AAK55424 BAB14449 BAG57961 EAW93930

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca