Version 5.4
Homo sapiens Protein: ST8SIA3
Summary
InnateDB Protein IDBP-3710.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST8SIA3
Protein Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000320431
InnateDB Gene IDBG-3708 (ST8SIA3)
Protein Structure
UniProt Annotation
Function May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid. {ECO:0000269PubMed:10766765, ECO:0000269PubMed:9826427}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in fetal and adult brain and fetal liver. {ECO:0000269PubMed:9826427}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
GO:0033691 sialic acid binding
Biological Process
GO:0001574 ganglioside biosynthetic process
GO:0006486 protein glycosylation
GO:0006491 N-glycan processing
GO:0006688 glycosphingolipid biosynthetic process
GO:0009100 glycoprotein metabolic process
GO:0009311 oligosaccharide metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0030173 integral component of Golgi membrane
Protein Structure and Domains
PDB ID
InterPro IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase
PFAM PF00777
PRINTS
PIRSF PIRSF005557
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43173
PhosphoSite PhosphoSite-O43173
TrEMBL Q59GW3
UniProt Splice Variant
Entrez Gene 51046
UniGene Hs.711721
RefSeq NP_056963
HUGO HGNC:14269
OMIM 609478
CCDS CCDS32834
HPRD 15343
IMGT
EMBL AB208996 AF003092 AF004668 AK289517 AK313047 BC074909
GenPept AAB87642 AAC15901 AAH74909 BAD92233 BAF82206 BAG35879

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca