InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FCHO2

Summary

InnateDB Protein

IDBP-371256.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCHO2

Protein Name

FCH domain only 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000393776

InnateDB Gene

IDBG-27912 (FCHO2)

Protein Structure

UniProt Annotation

Function

Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269PubMed:17540576, ECO:0000269PubMed:20448150, ECO:0000269PubMed:21762413, ECO:0000269PubMed:22323290}.

Subcellular Localization

Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0010324	membrane invagination
GO:0048268	clathrin coat assembly
GO:0072583	clathrin-mediated endocytosis
GO:0072659	protein localization to plasma membrane