InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNMT3B

Summary

InnateDB Protein

IDBP-371354.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNMT3B

Protein Name

DNA (cytosine-5-)-methyltransferase 3 beta

Synonyms

ICF; ICF1; M.HsaIIIB;

Species

Homo sapiens

Ensembl Protein

ENSP00000403169

InnateDB Gene

IDBG-65401 (DNMT3B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	110 [view]
Protein-Protein	106 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0009008	DNA-methyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0010628	positive regulation of gene expression
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0051573	negative regulation of histone H3-K9 methylation

Cellular Component

GO:0005634	nucleus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000313 PWWP domain
IPR001525 C-5 cytosine methyltransferase
IPR011011 Zinc finger, FYVE/PHD-type
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00855
PF00145

PRINTS

PR00105

PIRSF

SMART

SM00293

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt