InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTDSPL

Summary

InnateDB Protein

IDBP-371528.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTDSPL

Protein Name

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

Synonyms

C3orf8; HYA22; PSR1; RBSP3; SCP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000398288

InnateDB Gene

IDBG-25161 (CTDSPL)

Protein Structure

UniProt Annotation

Function

Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. {ECO:0000250, ECO:0000269PubMed:12721286}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expression is restricted to non-neuronal tissues. {ECO:0000269PubMed:15681389}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0046872	metal ion binding