Version 5.4
Homo sapiens Protein: MEMO1
Summary
InnateDB Protein IDBP-371728.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEMO1
Protein Name mediator of cell motility 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000400795
InnateDB Gene IDBG-43005 (MEMO1)
Protein Structure
UniProt Annotation
Function May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269PubMed:15156151, ECO:0000269PubMed:20937854}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0032886 regulation of microtubule-based process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR002737 MEMO1 family
PFAM PF01875
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y316
PhosphoSite PhosphoSite-Q9Y316
TrEMBL C9JSD7
UniProt Splice Variant
Entrez Gene 51072
UniGene Hs.645042
RefSeq NP_001131074
HUGO HGNC:14014
OMIM 611786
CCDS CCDS46255
HPRD 12814
IMGT
EMBL AB041018 AB041019 AF132961 AF363446 AF529368 AK297128 AL121652 AL121655 BC018733 BC070046 BC094681 CH471053
GenPept AAD27736 AAH18733 AAH70046 AAH94681 AAL34462 AAQ09602 BAD74066 BAD74067 BAG59632 EAX00467 EAX00469 EAX00470 EAX00472

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca