InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BIRC6

Summary

InnateDB Protein

IDBP-371931.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC6

Protein Name

baculoviral IAP repeat containing 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000393596

InnateDB Gene

IDBG-43545 (BIRC6)

Protein Structure

UniProt Annotation

Function

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269PubMed:14765125, ECO:0000269PubMed:15200957, ECO:0000269PubMed:18329369}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:18329369}. Midbody {ECO:0000269PubMed:18329369}. Endosome {ECO:0000269PubMed:18329369}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:18329369}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:18329369}. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.

Disease Associations

Tissue Specificity

Expressed in brain cancer cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	41 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0001890	placenta development
GO:0006464	cellular protein modification process
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007067	mitotic nuclear division
GO:0008284	positive regulation of cell proliferation
GO:0010951	negative regulation of endopeptidase activity
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0032465	regulation of cytokinesis
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0060711	labyrinthine layer development
GO:0060712	spongiotrophoblast layer development
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000922	spindle pole
GO:0005768	endosome
GO:0005802	trans-Golgi network
GO:0005815	microtubule organizing center
GO:0016020	membrane
GO:0030496	midbody

Protein Structure and Domains

PDB ID

InterPro

IPR000608 Ubiquitin-conjugating enzyme, E2
IPR001370 Baculoviral inhibition of apoptosis protein repeat
IPR008883 Ubiquitin E2 variant, N-terminal
IPR008979 Galactose-binding domain-like
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
IPR017986 WD40-repeat-containing domain
IPR022103 Baculoviral IAP repeat-containing protein 6

PFAM

PF00179
PF00653
PF05743
PF12356

PRINTS

PIRSF

SMART

SM00238

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NR09