InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRMT2

Summary

InnateDB Protein

IDBP-372029.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT2

Protein Name

protein arginine methyltransferase 2

Synonyms

HRMT1L1;

Species

Homo sapiens

Ensembl Protein

ENSP00000407463

InnateDB Gene

IDBG-6604 (PRMT2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016274	protein-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0030331	estrogen receptor binding
GO:0033142	progesterone receptor binding
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0042803	protein homodimerization activity
GO:0042974	retinoic acid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0046966	thyroid hormone receptor binding
GO:0050681	androgen receptor binding

Biological Process

GO:0006479	protein methylation
GO:0007165	signal transduction
GO:0016571	histone methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0034969	histone arginine methylation
GO:0043065	positive regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048588	developmental cell growth
GO:0060765	regulation of androgen receptor signaling pathway
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0035189	Rb-E2F complex

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR003402 tRNA transferase Trm5/Tyw2
IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR011511 Variant SH3 domain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00018
PF14604
PF02475
PF05175
PF06325
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt