Version 5.4
Homo sapiens Protein: THAP11
Summary
InnateDB Protein IDBP-37410.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THAP11
Protein Name THAP domain containing 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000304689
InnateDB Gene IDBG-37408 (THAP11)
Protein Structure
UniProt Annotation
Function Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:9853615}. Cytoplasm {ECO:0000250}. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0045171 intercellular bridge
Protein Structure and Domains
PDB ID
InterPro IPR006612 Zinc finger, C2CH-type
PFAM PF05485
PRINTS
PIRSF
SMART SM00692
SM00980
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96EK4
PhosphoSite PhosphoSite-Q96EK4
TrEMBL B5APZ3
UniProt Splice Variant
Entrez Gene 57215
UniGene Hs.632200
RefSeq NP_065190
HUGO HGNC:23194
OMIM 609119
CCDS CCDS10847
HPRD 11629
IMGT
EMBL AB015338 AK289367 BC012182 EF036502 EU869208
GenPept AAH12182 ABO65088 ACG50140 BAA34796 BAF82056

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca