InnateDB Protein
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IDBP-37478.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CAPZA2
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Protein Name
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capping protein (actin filament) muscle Z-line, alpha 2
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Synonyms
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CAPPA2; CAPZ;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000354947
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InnateDB Gene
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IDBG-37476 (CAPZA2)
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Protein Structure
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Function |
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
23
[view]
|
Protein-Protein |
21
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
1
[view]
|
DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
5 [view]
|
|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002189
F-actin-capping protein subunit alpha
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PFAM |
PF01267
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PRINTS |
PR00191
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P47755
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PhosphoSite |
PhosphoSite-P47755
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TrEMBL |
A4D0V4
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UniProt Splice Variant |
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Entrez Gene |
830
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UniGene |
Hs.446123
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RefSeq |
NP_006127
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HUGO |
HGNC:1490
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OMIM |
601571
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CCDS |
CCDS5768
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HPRD |
11871
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IMGT |
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EMBL |
AC002543
AK294409
AK314808
BC005338
BT006735
CH236947
CH471070
U03269
U03851
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GenPept |
AAA88848
AAC00534
AAC60382
AAH05338
AAP35381
BAG37333
BAG57661
EAL24358
EAW83513
EAW83515
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