InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACVRL1

Summary

InnateDB Protein

IDBP-375339.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACVRL1

Protein Name

activin A receptor type II-like 1

Synonyms

ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I;

Species

Homo sapiens

Ensembl Protein

ENSP00000392492

InnateDB Gene

IDBG-33826 (ACVRL1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0023014	signal transduction by phosphorylation

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt