Version 5.4
Homo sapiens Protein: TLCD1
Summary
InnateDB Protein IDBP-37558.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLCD1
Protein Name TLC domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000292090
InnateDB Gene IDBG-37556 (TLCD1)
Protein Structure
UniProt Annotation
Function Calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CACNA1C/CaV1.2 channel. Regulation of intracellular calcium by Calfacilitin is required for neural plate formation (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006634 TRAM/LAG1/CLN8 homology domain
PFAM PF03798
PRINTS
PIRSF
SMART SM00724
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96CP7
PhosphoSite PhosphoSite-Q96CP7
TrEMBL K7ELX5
UniProt Splice Variant
Entrez Gene 116238
UniGene Hs.713008
RefSeq NP_612472
HUGO HGNC:25177
OMIM
CCDS CCDS11242
HPRD 14015
IMGT
EMBL AC010761 BC014072
GenPept AAH14072

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca