InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MEF2B

Summary

InnateDB Protein

IDBP-376451.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEF2B

Protein Name

myocyte enhancer factor 2B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000390762

InnateDB Gene

IDBG-235890 (MEF2B)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in skeletal and cardiac muscle and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042826	histone deacetylase binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007517	muscle organ development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter