Homo sapiens Protein: MEF2B
Summary
InnateDB Protein IDBP-376459.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEF2B
Protein Name myocyte enhancer factor 2B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000402154
InnateDB Gene IDBG-235890 (MEF2B)
Protein Structure
UniProt Annotation
Function Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Expressed in skeletal and cardiac muscle and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0042826 histone deacetylase binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007517 muscle organ development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR002100 Transcription factor, MADS-box
PFAM PF00319
PRINTS PR00404
PIRSF
SMART SM00432
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q02080
PhosphoSite PhosphoSite-Q02080
TrEMBL A0A024R7K5
UniProt Splice Variant
Entrez Gene 100271849
UniGene Hs.153629
RefSeq NP_001139257
HUGO HGNC:6995
OMIM 600661
CCDS CCDS46024
HPRD
IMGT
EMBL AC002126 AK301086 AK316328 BC126245 BC136457 BC171767 CH471106 X63380 X68502
GenPept AAB86982 AAI26246 AAI36458 AAI71767 BAG62689 BAH14699 CAA44978 CAA48515 EAW84788 EAW84793