InnateDB Protein
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IDBP-376459.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MEF2B
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Protein Name
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myocyte enhancer factor 2B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000402154
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InnateDB Gene
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IDBG-235890 (MEF2B)
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Protein Structure
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Function |
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in skeletal and cardiac muscle and brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
|
Protein-Protein |
9
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0042826
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histone deacetylase binding
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GO:0046983
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protein dimerization activity
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0007517
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muscle organ development
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR002100
Transcription factor, MADS-box
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PFAM |
PF00319
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PRINTS |
PR00404
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PIRSF |
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SMART |
SM00432
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TIGRFAMs |
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Modification |
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SwissProt |
Q02080
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PhosphoSite |
PhosphoSite-Q02080
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TrEMBL |
A0A024R7K5
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UniProt Splice Variant |
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Entrez Gene |
100271849
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UniGene |
Hs.153629
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RefSeq |
NP_001139257
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HUGO |
HGNC:6995
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OMIM |
600661
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CCDS |
CCDS46024
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HPRD |
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IMGT |
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EMBL |
AC002126
AK301086
AK316328
BC126245
BC136457
BC171767
CH471106
X63380
X68502
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GenPept |
AAB86982
AAI26246
AAI36458
AAI71767
BAG62689
BAH14699
CAA44978
CAA48515
EAW84788
EAW84793
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