Version 5.4
Homo sapiens Protein: PGGT1B
Summary
InnateDB Protein IDBP-37709.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGGT1B
Protein Name protein geranylgeranyltransferase type I, beta subunit
Synonyms BGGI; GGTI;
Species Homo sapiens
Ensembl Protein ENSP00000368935
InnateDB Gene IDBG-37705 (PGGT1B)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. {ECO:0000269PubMed:8106351}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004661 protein geranylgeranyltransferase activity
GO:0004662 CAAX-protein geranylgeranyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0018344 protein geranylgeranylation
Cellular Component
GO:0005953 CAAX-protein geranylgeranyltransferase complex
Protein Structure and Domains
PDB ID
InterPro IPR001330 Prenyltransferase/squalene oxidase
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
PFAM PF00432
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P53609
PhosphoSite PhosphoSite-P53609
TrEMBL
UniProt Splice Variant
Entrez Gene 5229
UniGene Hs.254006
RefSeq
HUGO HGNC:8895
OMIM 602031
CCDS
HPRD 03612
IMGT
EMBL AC008494 AY780790 L25441
GenPept AAA35888 AAV98360

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca