InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERAL1

Summary

InnateDB Protein

IDBP-37768.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERAL1

Protein Name

Era G-protein-like 1 (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000254928

InnateDB Gene

IDBG-37766 (ERAL1)

Protein Structure

UniProt Annotation

Function

Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. {ECO:0000269PubMed:20430825, ECO:0000269PubMed:20604745}.

Subcellular Localization

Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0019843	rRNA binding
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000028	ribosomal small subunit assembly
GO:0007264	small GTPase mediated signal transduction
GO:0015684	ferrous iron transport

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0015629	actin cytoskeleton
GO:0016021	integral component of membrane
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001401 Dynamin, GTPase domain
IPR005225 Small GTP-binding protein domain
IPR006073 GTP binding domain
IPR006703 AIG1
IPR009019 K homology domain, prokaryotic type
IPR011619 Ferrous iron transport protein B, N-terminal
IPR013684 Mitochondrial Rho-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00350
PF01926
PF04548
PF02421
PF08477

PRINTS

PR00315
PR00326

PIRSF

SMART

SM00053

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt