InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNAI2

Summary

InnateDB Protein

IDBP-378040.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNAI2

Protein Name

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

Synonyms

GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000406369

InnateDB Gene

IDBG-36105 (GNAI2)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:17635935}. Cell membrane {ECO:0000269PubMed:17635935}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	91 [view]
Protein-Protein	91 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0006184	GTP catabolic process
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0007584	response to nutrient
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0045087	innate immune response (InnateDB)
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR002975 Fungal G-protein, alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00318
PR00441
PR01241
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt