InnateDB Protein
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IDBP-378369.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MORF4L2
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Protein Name
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mortality factor 4 like 2
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Synonyms
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MORFL2; MRGX;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000415476
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InnateDB Gene
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IDBG-80774 (MORF4L2)
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Protein Structure
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Function |
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
64
[view]
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Protein-Protein |
64
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR016197
Chromo domain-like
IPR026541
MRG domain
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PFAM |
PF05712
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15014
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PhosphoSite |
PhosphoSite-Q15014
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TrEMBL |
Q5JXX6
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UniProt Splice Variant |
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Entrez Gene |
9643
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UniGene |
Hs.618392
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RefSeq |
NP_001135904
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HUGO |
HGNC:16849
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OMIM |
300409
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CCDS |
CCDS14512
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HPRD |
02326
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IMGT |
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EMBL |
AB050778
AF100620
AF167174
AK056012
AK126115
AK302083
AL049610
BC056899
BC093013
CH471190
D14812
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GenPept |
AAD29873
AAF80855
AAH56899
AAH93013
BAA03553
BAC22659
BAG51604
BAG54288
BAG63470
CAB55701
EAW54698
EAW54699
EAW54700
EAW54701
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