Version 5.4
Homo sapiens Protein: CKLF
Summary
InnateDB Protein IDBP-378488.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CKLF
Protein Name chemokine-like factor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000416678
InnateDB Gene IDBG-281643 (CKLF)
Protein Structure
UniProt Annotation
Function May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10. {ECO:0000269PubMed:11415443}.Isoform 1 has chemotactic response in rat monocytes, neutrophils, and lymphocytes. {ECO:0000269PubMed:11415443}.
Subcellular Localization Isoform 1: Secreted.Isoform 2: Membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.Isoform 4: Membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver. {ECO:0000269PubMed:11415443}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0008283 cell proliferation
GO:0030593 neutrophil chemotaxis
GO:0032940 secretion by cell
GO:0048246 macrophage chemotaxis
GO:0048247 lymphocyte chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBR5
PhosphoSite PhosphoSite-Q9UBR5
TrEMBL
UniProt Splice Variant
Entrez Gene 51192
UniGene
RefSeq NP_001035228
HUGO HGNC:13253
OMIM
CCDS CCDS45502
HPRD 16718
IMGT
EMBL AC010542 AF057306 AF096895 AF135380 AF135381 AF145216 AF151058 AY358999 AY665769 BC004380
GenPept AAF06722 AAF19350 AAF19599 AAF19600 AAF21255 AAF36144 AAH04380 AAQ89358 AAT70694

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca