InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACNA2D2

Summary

InnateDB Protein

IDBP-378523.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA2D2

Protein Name

calcium channel, voltage-dependent, alpha 2/delta subunit 2

Synonyms

CACNA2D;

Species

Homo sapiens

Ensembl Protein

ENSP00000390329

InnateDB Gene

IDBG-37017 (CACNA2D2)

Protein Structure

UniProt Annotation

Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. {ECO:0000269PubMed:12555074, ECO:0000269PubMed:15111129}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with CACNA1A in lipid raft fractions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain. {ECO:0000269PubMed:10766861, ECO:0000269PubMed:11687876, ECO:0000269PubMed:9880589}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0034765	regulation of ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886

plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR004010 Cache domain
IPR013608 VWA N-terminal
IPR013680 Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region

PFAM

PF00092
PF02743
PF08269
PF08399
PF08473

PRINTS

PIRSF

SMART

SM00327
SM01049

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NY47