Version 5.4
Homo sapiens Protein: IK
Summary
InnateDB Protein IDBP-378535.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IK
Protein Name IK cytokine, down-regulator of HLA II
Synonyms CSA2; RED;
Species Homo sapiens
Ensembl Protein ENSP00000396301
InnateDB Gene IDBG-49207 (IK)
Protein Structure
UniProt Annotation
Function May bind to chromatin.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 88 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006955 immune response
GO:0007267 cell-cell signaling
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR012492 Protein RED, C-terminal
IPR012916 RED-like, N-terminal
PFAM PF07807
PF07808
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13123
PhosphoSite PhosphoSite-Q13123
TrEMBL E7EQZ7
UniProt Splice Variant
Entrez Gene 3550
UniGene Hs.421245
RefSeq NP_006074
HUGO HGNC:5958
OMIM 600549
CCDS CCDS47280
HPRD 02771
IMGT
EMBL AC116353 AJ005579 AK293626 BC071964 S74221
GenPept AAB32531 AAH71964 BAG57083 CAA06607

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca