Version 5.4
Homo sapiens Protein: FAM96B
Summary
InnateDB Protein IDBP-378758.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM96B
Protein Name family with sequence similarity 96, member B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000387471
InnateDB Gene IDBG-35793 (FAM96B)
Protein Structure
UniProt Annotation
Function Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. {ECO:0000269PubMed:20797633}.
Subcellular Localization Nucleus {ECO:0000269PubMed:20797633}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:20797633}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007059 chromosome segregation
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0071817 MMXD complex
GO:0097361 CIA complex
Protein Structure and Domains
PDB ID
InterPro IPR002744 Domain of unknown function DUF59
PFAM PF01883
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y3D0
PhosphoSite PhosphoSite-Q9Y3D0
TrEMBL J3QLT9
UniProt Splice Variant
Entrez Gene 51647
UniGene Hs.636360
RefSeq NP_057146
HUGO HGNC:24261
OMIM 614778
CCDS CCDS45506
HPRD 13033
IMGT
EMBL AC009084 AF151886 AF161467 BC001733 BC005023
GenPept AAD34123 AAF29082 AAH01733 AAH05023

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca