InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MORF4L1

Summary

InnateDB Protein

IDBP-378774.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MORF4L1

Protein Name

mortality factor 4 like 1

Synonyms

Eaf3; HsT17725; MEAF3; MORFRG15; MRG15; S863-6;

Species

Homo sapiens

Ensembl Protein

ENSP00000408880

InnateDB Gene

IDBG-25183 (MORF4L1)

Protein Structure

UniProt Annotation

Function

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. {ECO:0000269PubMed:14966270, ECO:0000269PubMed:20332121}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	85 [view]
Protein-Protein	85 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016575	histone deacetylation
GO:0040008	regulation of growth
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016580	Sin3 complex
GO:0035267	NuA4 histone acetyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000953 Chromo domain/shadow
IPR016197 Chromo domain-like
IPR017398 Chromatin modification-related protein EAF3/MRG15
IPR025995 RNA binding activity-knot of a chromodomain
IPR026541 MRG domain

PFAM

PF11717
PF05712

PRINTS

PIRSF

PIRSF038133

SMART

SM00298

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt