InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL24

Summary

InnateDB Protein

IDBP-379494.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL24

Protein Name

chemokine (C-C motif) ligand 24

Synonyms

Ckb-6; MPIF-2; MPIF2; SCYA24;

Species

Homo sapiens

Ensembl Protein

ENSP00000400533

InnateDB Gene

IDBG-22726 (CCL24)

Protein Structure

UniProt Annotation

Function

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Activated monocytes and activated T lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008009	chemokine activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008360	regulation of cell shape
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0032855	positive regulation of Rac GTPase activity
GO:0045766	positive regulation of angiogenesis
GO:0048245	eosinophil chemotaxis
GO:0050729	positive regulation of inflammatory response
GO:2000418	positive regulation of eosinophil migration