InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGBL1

Summary

InnateDB Protein

IDBP-379793.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGBL1

Protein Name

ATP/GTP binding protein-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000413001

InnateDB Gene

IDBG-28295 (AGBL1)

Protein Structure

UniProt Annotation

Function

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:24094747}.

Disease Associations

Corneal dystrophy, Fuchs endothelial, 8 (FECD8) [MIM:615523]: A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. {ECO:0000269PubMed:24094747}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in corneal endothelium. {ECO:0000269PubMed:24094747}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004181	metallocarboxypeptidase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0015631	tubulin binding