Version 5.4
Homo sapiens Protein: STRBP
Summary
InnateDB Protein IDBP-379836.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STRBP
Protein Name spermatid perinuclear RNA binding protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000415968
InnateDB Gene IDBG-84487 (STRBP)
Protein Structure
UniProt Annotation
Function Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=Microtubule- associated that localizes to the manchette in developing spermatids. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006928 cellular component movement
GO:0007275 multicellular organismal development
GO:0007286 spermatid development
GO:0007638 mechanosensory behavior
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR006561 DZF domain
IPR014720 Double-stranded RNA-binding domain
PFAM PF07528
PF00035
PRINTS
PIRSF
SMART SM00572
SM00358
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96SI9
PhosphoSite PhosphoSite-Q96SI9
TrEMBL V9HWK4
UniProt Splice Variant
Entrez Gene 55342
UniGene Hs.721568
RefSeq XP_005252140
HUGO HGNC:16462
OMIM 611138
CCDS CCDS6851
HPRD 10257
IMGT
EMBL AF333337 AK002169 AK024285 AK027890 AL136866 AL365338 AL365504 BC002693 BC017732 BC108731 CH471090 EU794683
GenPept AAH02693 AAH17732 AAI08732 AAK20832 ACJ13737 BAA92120 BAB14873 BAB55434 CAB66800 CAH70299 CAH70300 EAW87564

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca