InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFATC3

Summary

InnateDB Protein

IDBP-38036.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFATC3

Protein Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Synonyms

NFAT4; NFATX;

Species

Homo sapiens

Ensembl Protein

ENSP00000300659

InnateDB Gene

IDBG-38028 (NFATC3)

Protein Structure

UniProt Annotation

Function

Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. {ECO:0000269PubMed:18815128}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18815128}. Nucleus {ECO:0000269PubMed:18815128}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Disease Associations

Tissue Specificity

Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	8 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006954	inflammatory response
GO:0007507	heart development
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045333	cellular respiration
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051145	smooth muscle cell differentiation
GO:0055001	muscle cell development
GO:0071277	cellular response to calcium ion
GO:0071285	cellular response to lithium ion

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002909 IPT domain
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set

PFAM

PF01833
PF00554

PRINTS

PR01789

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt