Version 5.4
Homo sapiens Protein: SORBS2
Summary
InnateDB Protein IDBP-380668.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORBS2
Protein Name sorbin and SH3 domain containing 2
Synonyms ARGBP2; PRO0618;
Species Homo sapiens
Ensembl Protein ENSP00000396008
InnateDB Gene IDBG-47102 (SORBS2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 45 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008093 cytoskeletal adaptor activity
GO:0008307 structural constituent of muscle
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0008150 biological_process
GO:0016477 cell migration
Cellular Component
GO:0005634 nucleus
GO:0015629 actin cytoskeleton
GO:0030018 Z disc
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR003127 Sorbin-like
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF02208
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
SM00459
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O94875
PhosphoSite PhosphoSite-O94875
TrEMBL C9JL62
UniProt Splice Variant
Entrez Gene 8470
UniGene Hs.742471
RefSeq NP_001139145
HUGO HGNC:24098
OMIM
CCDS CCDS47175
HPRD 12473
IMGT
EMBL AB018320 AC093797 AC096659 AC104805 AC108472 AF049884 AF049885 AK056628 AK225327 AK225812 AK293400 AK296461 BC011883 CH471056
GenPept AAC05508 AAC05509 AAH11883 BAA34497 BAG51769 BAH11501 BAH12362 EAX04630 EAX04631 EAX04632 EAX04635 EAX04636

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca