Version 5.4
Homo sapiens Protein: KIF4B
Summary
InnateDB Protein IDBP-380756.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF4B
Protein Name kinesin family member 4B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000387875
InnateDB Gene IDBG-306447 (KIF4B)
Protein Structure
UniProt Annotation
Function Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000305}.
Disease Associations
Tissue Specificity Specifically expressed in testis. {ECO:0000269PubMed:16201836}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0016363 nuclear matrix
Protein Structure and Domains
PDB ID
InterPro IPR001752 Kinesin, motor domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00225
PRINTS PR00380
PIRSF
SMART SM00129
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2VIQ3
PhosphoSite PhosphoSite-Q2VIQ3
TrEMBL
UniProt Splice Variant
Entrez Gene 285643
UniGene Hs.567824
RefSeq NP_001092763
HUGO HGNC:6322
OMIM 609184
CCDS CCDS47324
HPRD
IMGT
EMBL AF241316 DQ120629
GenPept ABB92415

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca