Version 5.4
Homo sapiens Protein: LIME1
Summary
InnateDB Protein IDBP-381120.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIME1
Protein Name Lck interacting transmembrane adaptor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000414506
InnateDB Gene IDBG-87257 (LIME1)
Protein Structure
UniProt Annotation
Function Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269PubMed:14610046}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:14610044, ECO:0000269PubMed:14610046}; Single-pass type III membrane protein {ECO:0000269PubMed:14610044, ECO:0000269PubMed:14610046}. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
Disease Associations
Tissue Specificity Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level). {ECO:0000269PubMed:14610044, ECO:0000269PubMed:14610046, ECO:0000269PubMed:16160011}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
Cellular Component
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9H400
TrEMBL X6RKG5
UniProt Splice Variant
Entrez Gene 54923
UniGene
RefSeq
HUGO HGNC:26016
OMIM 609809
CCDS
HPRD 07904
IMGT
EMBL AL121845
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca