InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO7A

Summary

InnateDB Protein

IDBP-381427.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO7A

Protein Name

myosin VIIA

Synonyms

DFNA11; DFNB2; MYOVIIA; MYU7A; NSRD2; USH1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000392185

InnateDB Gene

IDBG-65343 (MYO7A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0030507	spectrin binding
GO:0046983	protein dimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0007040	lysosome organization
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0008152	metabolic process
GO:0030048	actin filament-based movement
GO:0042462	eye photoreceptor cell development
GO:0050953	sensory perception of light stimulus
GO:0050957	equilibrioception

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005938	cell cortex
GO:0016459	myosin complex
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000299 FERM domain
IPR000857 MyTH4 domain
IPR001452 SH3 domain
IPR001609 Myosin head, motor domain
IPR018979 FERM, N-terminal
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029071 Ubiquitin-related domain

PFAM