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InnateDB Protein
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IDBP-381958.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATP11C
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Protein Name
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ATPase, class VI, type 11C
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000391259
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InnateDB Gene
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IDBG-87951 (ATP11C)
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Protein Structure
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| Function |
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cell membrane {ECO:0000269PubMed:21914794}; Multi-pass membrane protein {ECO:0000269PubMed:21914794}. Endoplasmic reticulum membrane {ECO:0000269PubMed:21914794}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:15533723}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
2
[view]
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| Protein-Protein |
2
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q8NB49
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
286410
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| UniGene |
Hs.88252
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| RefSeq |
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| HUGO |
HGNC:13554
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| OMIM |
300516
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| CCDS |
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| HPRD |
09814
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4