InnateDB Protein
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IDBP-382052.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMEM100
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Protein Name
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transmembrane protein 100
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000395328
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InnateDB Gene
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IDBG-60080 (TMEM100)
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Protein Structure
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Function |
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. {ECO:0000250}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system.
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Disease Associations |
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Tissue Specificity |
Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system. Expressed in umbilical artery endothelial cells (at protein level). {ECO:0000269PubMed:22783020, ECO:0000269PubMed:23485812}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NV29
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PhosphoSite |
PhosphoSite-Q9NV29
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55273
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UniGene |
Hs.741537
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RefSeq |
NP_060756
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HUGO |
HGNC:25607
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OMIM |
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CCDS |
CCDS11587
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HPRD |
07719
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IMGT |
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EMBL |
AC009837
AK001832
BC010128
CH471109
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GenPept |
AAH10128
BAA91931
EAW94537
EAW94538
EAW94539
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