Version 5.4
Homo sapiens Protein: RPL10
Summary
InnateDB Protein IDBP-383540.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPL10
Protein Name ribosomal protein L10
Synonyms AUTSX5; DXS648; DXS648E; L10; NOV; QM;
Species Homo sapiens
Ensembl Protein ENSP00000388600
InnateDB Gene IDBG-91249 (RPL10)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations Autism, X-linked 5 (AUTSX5) [MIM:300847]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269PubMed:16940977, ECO:0000269PubMed:21567917}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
Experimentally validated
Total 95 [view]
Protein-Protein 92 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005840 ribosome
Protein Structure and Domains
PDB ID
InterPro IPR001197 Ribosomal protein L10e
IPR016180 Ribosomal protein L10e/L16
PFAM PF00252
PRINTS
PIRSF PIRSF005590
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-P27635
TrEMBL X1WI28
UniProt Splice Variant
Entrez Gene 6134
UniGene Hs.739235
RefSeq
HUGO HGNC:10298
OMIM 312173
CCDS
HPRD 02421
IMGT
EMBL BX936346 BX936347
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca